Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors

Antisense oligodeoxynucleotides were used to determine whether alterations in the expression of N-methyl-D-aspartate (NMDA) receptor subunit mRNA are responsible for developmental changes in the sensitivity of receptors to agonists and antagonists. Xenopus laevis oocytes were injected with mRNA prepared from neonatal and adult rat cerebral cortex, and the effects of agonists and antagonists were determined under voltage-clamp conditions. Glycine-site antagonists like 7-chlorokynurenate and glutamate-site antagonists like CGP-39653 were more potent at NMDA receptors expressed from mRNA from adult rat cerebral cortex than those expressed from mRNA from 1-day-old rat. NMDA receptors from 1-day-old rat cerebral cortex were more sensitive to activation by glycine than were receptors from adult rat cerebral cortex. 7-Chlorokynurenate and CGP-39653 were more potent inhibitors of responses seen with heteromeric NR1/NR2A receptors than with NR1/ NR2B receptors. Conversely, heteromeric NR1/NR2B receptors were more sensitive to activation by glycine than were NR1/NR2A receptors. We previously described a delay in the expression of the NR2A subunit in developing rat brain. Anti-sense oligodeoxynucleotides were used to determine whether the delayed expression of the NR2A subunit underlies changes in pharmacological properties observed during development. The properties of receptors seen when adult brain mRNA was coinjected with antisense oligodeoxynucleotides against the NR2A subunit were similar to those found in receptors from 1-day-old rat brain. These data suggest that changes in the sensitivity of NMDA receptors to antagonists and to glycine seen during development are a result of alterations in the expression of different species of NR2 subunit mRNA.     

Finite twist and extension of a cylindrical elastic membrane

Summary We consider a circular cylindrical membrane subjected to longitudinal extension and twist. The associated equilibrium deformation is considered to be axisymmetric and the analysis is based on a direct two-dimensional formulation. Wrinkling of the membrane is taken into account in an approximate way by introducing arelaxed strain energy function derived from the neo-Hookean strain energy for isotropic elastic solids. Analytical formulae for wrinkled parts of the membrane are used to corroborate the results of a numerical treatment of the full boundary value problem.Dedicated to the memory of A. C. Pipkin     

离散动态系统及其应用（Ⅲ）─市场价格模型的数学分析

本文应用动力系统的定性分析方法，对离散市场价格模型作出全局分析，给出了关于离散市场价格系统的稳定性和分支结构的若干定理及其经济意义．     

数字式速度比例同步电脑控制系统

数字式速度比例同步控制系统，是把先进的交流变频调速技术，微电子技术和节能效果显著的永磁同步电机融为一体组成的性能优良的调速控制系统。该系统具有调速精度高调整范围大、稳定性好、抗干扰能力强、调整方便、节电效果显著等一系列优点。本文详细介绍了该系统的工作原理，并通过应用实例和分析对比，阐述该系统的优越性。     

稠油油藏的注汽量预测

利用HCZ预测模型，可对已开发油田的年产量和累计产量进行全程预测，并且在实际应用中取得了较好的预测结果。本文结合稠油田的实际情况，推导出HXZ预测模型在热采中注汽参数的预测公式。结合曙光油田曙1－7－5块的开发数据进行了预测，效果较好。     

含能材料分子结构与感度的相关性

综述了国外近年来含能材料分子结构参数与感度相关关系的最新研究成果。研究表明：某些芳香族硝基化合物的撞击感度与Ｃ－ＮＯ２键强度有关；硝胺及脂肪族硝基化合物的冲击波感度与分子中Ｎ－ＮＯ２键的数目，长度和分子量相关。     

用于多种组装技术的厚膜导体复合结构

厚膜导体Ｐｄ－Ａｇ／Ａｕ、Ｐｔ－Ｐｄ－Ａｕ／Ａｕ平面复合结构，Ｐｄ－Ａｇ／Ａｕ立体复合结构可使多种组装技术相互兼容。立体复合结构还可有效地降低导体线电阻，减少线损耗。而且，其超声键合性尤佳     

野外观测系统的检验与校正

在地震资料处理中常常发现野外观测系统不准,其后果极为严重。为了避免重复施工,改善处理效果,笔者在IBM3081系统上编制了利用初至波对野外观测系统进行检验和校正的程序。文中介绍了两种校正方法:其一是只作炮检距校正。根据工区的小折射、井口时间、反射记录等资料提供一条或几条比较准确的初至时距曲线,作为标准曲线,然后将从实际共炮点道集中拾取的初至曲线与标准初至时距曲线相比较,确定出实际初至曲线所对应的炮检距,并对各个地震道的空间属性进行修改。对某三维工区的处理结果表明,该方法的效果良好。其二是先用迭代方法加误差约束条件计算炮点和检波点的坐标,然后计算炮检距,再进行校正。这种校正处理的效果也是明显的。但实验表明,对于观测系统误差较大的数据,不宜作坐标计算,只作炮检距校正尚可完成部分校正。处理中要根据数据的性质选取校正方法。     

重油催化裂化装置轴流风机的损坏与修复

广州分公司炼油厂重油催化裂化装置四机组轴流风机在 1998年 9月由于入口消音器故障引发重大事故 ,严重影响了装置生产。该文主要针对其损坏的原因、情况和修复方法作了探讨和论述